“Here is how it will be: I am sending you out like sheep among wolves; therefore you should be as crafty [Note: The Greek word here is “sensible”] as snakes, yet as harmless [Note: The Greek word is “sincere”] as doves.
While Jesus was still speaking to the large crowds, His mother and [half-] brothers were standing outside [of the large house. See 13:1] wanting to speak to Him.
When His relatives [or friends] heard about this [i.e., all that He was doing], they went out to take custody of Him [for safety reasons (?)], for people were saying, “He has lost his mind.”
So, Jesus stopped traveling publicly among the Jews [in Judea], but left there and went to a district near the desert, to a town called Ephraim, where He remained with His disciples. [Note: Ephraim was a small town about 14 miles northeast of Jerusalem, near Samaria].
Then Jesus’ [half-] brothers said to Him, “You should leave here and go to Judea so your disciples [there] can see the [supernatural] deeds you are performing.
But, when [God’s] timing fully arrived, He sent His Son, born to a woman [i.e., Mary], born during [the time when] the Law [of Moses was still in effect],